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For our SNP-HSI association testing, we followed the model employed by systemic GWAS analyses for a multitude of phenotypes (see adjusting for the following covariates: sex, age, age 2 , age sex, age 2 sex, and PC eigenvectors, with the age 2 and interaction terms among the age and sex variables intended to account for non-linear associations

In addition, a recent real-world study conducted by PMI has found that subjects who switched from cigarettes to THS for at least 2 years showed favorable differences in nine biomarkers of potential harm (BoPH), compared with current smokers

The FDAs main tools against e-cigarette manufacturers are warning letters, which put companies on notice for violating FDA rules but are not legally binding

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