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The binding of TDP-43 to RNAs encoding HD-associated genes, many of which are differentially expressed and aberrantly spliced, is significantly reduced

In recent years, the escalating global prevalence of PCOS has been observed, and pharmacological intervention has become the primary treatment approach

Several possible reasons for the lack of efficacy of antioxidants in clinical trials include (i) insufficient antioxidant levels in the target organ, especially in the nervous system, because an integrated bloodbrain barrier (BBB) is a major obstacle to delivering desired substances, including antioxidants, into the CNS

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