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10.1161/cir.0000000000 45 GuL.BaiW.LiS.ZhangY.HanY.GuY.et al (2013)

In cases with -thalassemia, some polymorphisms of the heme oxygenase-1 (HO-1) gene, especially repeat mutations in the dinucleotide (GT) promoter region, induce the HO-1 gene to generate reactive oxygen species (ROS), which protects the cell [24] ( Fig