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Description

DOI: 10.1210/en.2005-0939 30

Published literature documents this approach based on non-competing receptor pathways

Although it is significantly shorter than the naturally occurring hormone, it retains the ability to bind to GHRH receptors in the pituitary gland and trigger growth hormone secretion

CJC-1295 with DAC binds to albumin for a 6-8 day half-life, enabling weekly dosing but producing sustained rather than pulsatile GH elevation which may blunt natural GH rhythms over time