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In summary, the study demonstrates that FOXO4-DRI effectively eliminates senescent Leydig cells, improves the testicular microenvironment, and alleviates age-related testosterone secretion insufficiency, highlighting its therapeutic potential for male late-onset hypogonadism [1]

The landmark Rudman study demonstrated that GH restoration in older men produced significant improvements in lean mass, fat mass, and skin thickness (9)

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If approved , cagrilintide could become a first-line option in pharmacologic obesity management , especially within aesthetic settings where facial fullness, contouring, and body composition improvements are key patient goals