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In this case, we recommend refrigerating or freezing the sealed products to store them

Circ Res 90, 143150 (2002)

Due to the extended duration of endocrine therapy, patients often face both on-treatment side effectssuch as hot flashes, fatigue, muscle pain, mood changes, vaginal symptoms, gastrointestinal issues, headaches, weight gain, and bone density lossas well as long-term effects, including an increased risk of heart disease and stroke, osteoporosis, memory problems or difficulty with concentration, secondary cancers, sexual dysfunction, chronic fatigue, joint pain and stiffness, and metabolic changes [23, 24]

The PLS-DA and heat map in Figure 1 show that resistant cells treated continuously with 1 M tamoxifen (4+1), a concentration that is often measured in patients (24), showed different metabolic clusters compared to the other two resistant groups (50 and 35x6) and the control (tamoxifen-sensitive) group, indicating that they had markedly different metabolic characteristics ( Figure 1A )