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9 Ways Smoking Can Worsen Your Diabetes GoodRx Nicotine and Blood Sugar: Does Nicotine Affect Blood Sugar? Smoking increases your risk for type 2 diabetes and makes diabetes management harder. Insulin helps blood sugar enter cells, but nicotine changes cells so they don't respond to insulin, which increases blood do cigarettes lower blood sugar Smoking and diabetes: How smoking can affect your blood sugar levels?
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