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Furthermore, similar to bacteria (Prinz et al ., 1997), a quadruple trx1 trx2 grx1 grx2 yeast mutant is nonviable and a single functional disulphide reductase system is necessary for viability (Draculic et al ., 2000)

A novel complex neurological phenotype due to a homozygous mutation in FDX2

565 The disturbance of iron homeostasis in the brain and ferroptosis of neurons can exacerbate neuroinflammation, causing abnormal microglial activation